Is it better to have ER positive or negative breast cancer? The survival rate for breast cancers are excellent if the cancer is detected early, and in general HR positive cancers grow slower and have a better prognosis. Overall, breast cancers that are both HR positive and HER2 negative have the best outcomes.
Is chemo necessary for ER positive? Most instances of ER-positive, HER2-negative, node-negative breast cancer <1 cm, and all cancers ≤0.5 cm, have a sufficiently good prognosis with endocrine therapy alone, that they do not typically require adjuvant chemotherapy.
Does ER positive breast cancer come back? Studies have shown that estrogen-receptor-positive breast cancer has a more drawn-out risk of recurrence compared to estrogen-receptor-negative disease. About 50% of estrogen-receptor-positive breast cancer recurrences happen 5 or more years after the initial diagnosis.
What is the meaning of ER positive? PAH-zih-tiv) Describes cells that have a protein that binds to the hormone estrogen. Cancer cells that are ER positive may need estrogen to grow. These cells may stop growing or die when treated with substances that block the binding and actions of estrogen. Also called estrogen receptor positive.
Is it better to have ER positive or negative breast cancer? – Additional Questions
What cancers are ER positive?
Hormone status of breast cancers includes: Estrogen receptor (ER) positive. The cells of this type of breast cancer have receptors that allow them to use the hormone estrogen to grow. Treatment with anti-estrogen hormone (endocrine) therapy can block the growth of the cancer cells.
Is estrogen receptor-positive a good thing?
Hormone receptor-positive cancers tend to grow more slowly than those that are hormone receptor-negative. Women with hormone receptor-positive cancers tend to have a better outlook in the short-term, but these cancers can sometimes come back many years after treatment.
What does ER mean in medical terms?
Medical Definition of emergency room
: a hospital room or area staffed and equipped for the reception and treatment of persons with conditions (as illness or trauma) requiring immediate medical care.
What is ER on a pathology report?
A protein found inside the cells of the female reproductive tissue, some other types of tissue, and some cancer cells. The hormone estrogen will bind to the receptors inside the cells and may cause the cells to grow. Also called estrogen receptor.
What does estrogen and progesterone receptor positive mean?
A breast cancer is estrogen receptor-positive if it has receptors for estrogen. This suggests that the cancer cells, like normal breast cells, may receive signals from estrogen that tell the cells to grow. The cancer is progesterone receptor-positive if it has progesterone receptors.
What does HER2 negative mean?
What HER2-negative means. If breast cancer cells don’t have abnormal levels of HER2 proteins, the breast cancer is considered HER2-negative. Even if your cancer is HER2-negative, it may still be estrogen-positive or progesterone-positive. Whether or not it’s hormone-positive also affects your treatment options.
Can HER2-positive be cured?
HER2-positive breast cancer is highly curable because of the availability of these HER2-targeted therapies, so we treat patients fairly aggressively upfront to reduce the risk of them experiencing a stage IV recurrence.
How do you stop HER2 recurrence?
Vaccine Derived from HER2 Protein May Help Prevent Breast Cancer Recurrence. A new breast cancer vaccine that is derived from the HER2 protein may help prevent recurrence in patients with HER2-positive disease and appears safe.
Does HER2-positive mean metastatic?
Since this protein can make cancer cells grow more quickly, it’s natural to worry that your HER2-positive breast cancer might spread, or “metastasize.” If breast cancer spreads to other parts of your body, doctors call it “metastatic.” That means it’s at a more advanced stage than if it’s only in your breasts.
How long can you live with HER2?
The survival rate among patients differ based on the molecular subtype and stage. The survival rate at four years among women with HR+/HER2− is estimated to be 92.5%, followed by HR+/HER2+ at 90.3%, HR−/HER2+ at 82.7%, and HR−/HER2− at 77.0% [1].
When is chemo not recommended?
Your oncologist may recommend avoiding chemotherapy if your body is not healthy enough to withstand chemotherapy or if there is a more effective treatment available.
Does HER2+ Always Come Back?
HER2-positive breast cancer is more aggressive and more likely to recur, or return, than HER2-negative breast cancer. Recurrence can happen anytime, but it usually takes place within 5 years of treatment. The good news is that recurrence is less likely now than ever before.
Which cancers are most likely to recur?
Cancers with the highest recurrence rates include: Glioblastoma, the most common type of brain cancer, has a near 100 percent recurrence rate, according to a study published in the Journal of Neuro-Oncology.
How long is chemo for HER2-positive?
Neoadjuvant therapy is typically administered for between 12 and 20 weeks, depending on the chosen regimen, and followed by surgery. When given as adjuvant chemotherapy following surgery, trastuzumab is given concurrently with chemotherapy, then continued for a total duration of 12 months.
Where does HER2 recur?
Two studies found that even small (1 cm or smaller), early-stage, HER2-positive breast cancers are more likely to come back (recur) and spread to parts of the body away from the breast (metastasize) than small, early-stage, HER2-negative breast cancers.
What triggers HER2-positive?
The exact cause of HER2-positive breast cancer is unknown, but it is believed environment, lifestyle, and genetics may be factors. Risk factors for developing breast cancer in general include: Being a woman. Inherited genes, including BRCA1 and BRCA2 and others.
How can I lower my HER2 protein naturally?
Black pepper contains an active compound called piperine. Research in a lab setting suggested that piperine has an anti-tumor effect on HER2-positive breast cancer cells. This means that it stops the cells from growing and causes them to die. Piperine was also found to stop the HER2 gene from making HER2 proteins.
