Exemestane Worsens Bone Loss in Postmenopausal Women
February 7, 2012
Exemestane (Aromasin) may cause substantial bone loss, according to a study published in Lancet Oncology. The aromatase inhibitor, which has been suggested to reduce the risk of getting breast cancer, may in fact pose significant harm to bone health in postmenopausal women.
To examine the safety of exemestane on bone health, Dr. Angela Cheung and colleagues conducted a nested safety substudy within the Mammary Prevention 3 (MAP.3) trial. MAP.3 is a randomized, placebo-controlled, double-blind trial of exemestane 25 mg a day for the primary prevention of breast cancer in healthy, postmenopausal women considered at "high risk" for the disease. In this substudy, 176 women (median age of 61.3 years) were given exemestane and 175 were assigned to placebo. The primary endpoint was percent change from baseline to 2 years in total volumetric bone mineral density (BMD) at the distal radius (wrist) by high-resolution peripheral quantitative CT. Normal, age-related bone loss was expected in all women. At the time of the analysis, 242 women had completed the 2-year follow-up: 124 and 118 in the exemestane and placebo groups, respectively.
After two years of follow-up, the mean percent change in total volumetric BMD at the distal radius was −6.1% in the exemestane group and −1.8% in the placebo group. The results also suggested large and significant decreases in total volumetric BMD at the distal tibia (-5.0% versus -1.3%). "Women considering exemestane for the primary prevention of breast cancer should weigh their individual risks and benefits. For women taking exemestane, regular bone monitoring plus adequate calcium and vitamin D supplementation are important," conclude the authors.
MYTHS VS. TRUTHS
Brush up on your breast cancer myths and truths. Find out if you know more about breast cancer than the American public.
I'll Talk
Speak up and out about breast cancer. Say, "I'll Talk" and commit to a conversation about breast cancer with people you know and care about.

Understanding Research and Evidence
Comments
Cheap Beats By Dre
Date: May 4, 2012Tina2
Date: May 7, 2012Nike tn
Date: May 15, 2012Nike Basketball took some time out of Nike Tn the day to officially Tn Requin unveil their 2012 NBA All-Star Game Collection and it Nike Tn looks great. The shoes Tn Pas Cher drop includes three Coach Outlet Online silhouettes that are given a bit of Nike TN Tn Pas Cher an intergalactic spark thanks to an Air & Space theme that is complete with a glow in Tn Requin the dark outsole.Coach Outlet Included in the drop are the Coach Outlet Store Online Nike Zoom KD 4, Nike LeBron 9 and Nike Nike tn requin Zoom Kobe 7 and each one features a very solid colorway with a Tn Pas Cher vibrant outsole.
You have seen a few Five Finger Shoes posts about the Vibram five finger new Vibram FiveFingers Speed colorways Vibram FiveFingers that have been released this Vibram FiveFingers month. I was quite fond of Five Finger Shoes the Orange and Green Vibram five finger pair as well as the Brown and Tan pair. Once I saw Vibram Five Fingers that they were available at TravelCountry, Vibram Shoes I jumped on the chance to Vibram 5 Fingers pick up both of them.
Hermes’ street style shots with Hermes Replica Bag actual accessories attached Hemes Bracelet to them in the windows offers a very Hermes Bag refreshing concept. I’ve liked Hermes Birkin Bag street style fashion photography Hermes Replica Bag ever since university; it was Hermes Belt our way of finding out new directions in fashion, Hermes Bag and a lot of companies use Hermes Birkin Bag this technique to make their Coach Factory Outlet fashion seem like it’s emerging from the streets.
Nike Shox
Date: May 15, 2012cheap beats by dre
Date: May 16, 2012yama740
Date: May 17, 2012yama740
Date: May 17, 2012