What does it mean when we say that the breast cancer is hormone receptor positive? A breast cancer is estrogen receptor-positive if it has receptors for estrogen. This suggests that the cancer cells, like normal breast cells, may receive signals from estrogen that tell the cells to grow. The cancer is progesterone receptor-positive if it has progesterone receptors.

What does it mean to be hormone receptor positive? Listen to pronunciation. (HOR-mone reh-SEP-ter PAH-zih-tiv) Describes cells that have a group of proteins that bind to a specific hormone. For example, some breast cancer cells have receptors for the hormones estrogen or progesterone.

What is the survival rate for hormone positive breast cancer? 

5-year survival rates
Stage at diagnosis Percentage living after 5 years
localized (hasn’t spread outside the breast) 99 percent
regional (has spread to nearby tissue or lymph nodes) 86 percent
distant (has spread to distant organs) 28 percent
all stages combined 90 percent

Is it better to be hormone receptor positive or negative? Hormone receptor-positive cancers tend to grow more slowly than those that are hormone receptor-negative. Women with hormone receptor-positive cancers tend to have a better outlook in the short-term, but these cancers can sometimes come back many years after treatment.

What does it mean when we say that the breast cancer is hormone receptor positive? – Additional Questions

Is it better to be HER2-negative or positive?

Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. These cancers tend to grow and spread faster than breast cancers that are HER2-negative, but are much more likely to respond to treatment with drugs that target the HER2 protein.

When is chemo not recommended?

Your oncologist may recommend avoiding chemotherapy if your body is not healthy enough to withstand chemotherapy or if there is a more effective treatment available.

What does hormone receptor negative mean?

Listen to pronunciation. (HOR-mone reh-SEP-ter NEH-guh-tiv) Describes cells that do not have a group of proteins that bind to a specific hormone. For example, some breast cancer cells do not have receptors for the hormones estrogen or progesterone.

Is it good to be ER-positive?

In general, ER-positive, HER2-negative breast cancers that are low grade, strongly ER and progesterone receptor (PR) positive, with low measures of proliferation have a good prognosis with endocrine treatment alone.

What happens if the ER PR is negative?

Hormone receptor-negative breast cancer cells don’t have receptors for either estrogen (ER) or progesterone (PR). This means the cancer cells don’t grow in response to hormones. Hormone receptor-negative breast cancer accounts for about 25 to 30 percent of breast cancers.

What does HER2-negative mean?

What HER2-negative means. If breast cancer cells don’t have abnormal levels of HER2 proteins, the breast cancer is considered HER2-negative. Even if your cancer is HER2-negative, it may still be estrogen-positive or progesterone-positive. Whether or not it’s hormone-positive also affects your treatment options.

Can HER2-positive be cured?

HER2-positive breast cancer is highly curable because of the availability of these HER2-targeted therapies, so we treat patients fairly aggressively upfront to reduce the risk of them experiencing a stage IV recurrence.

Does HER2-positive mean metastatic?

Since this protein can make cancer cells grow more quickly, it’s natural to worry that your HER2-positive breast cancer might spread, or “metastasize.” If breast cancer spreads to other parts of your body, doctors call it “metastatic.” That means it’s at a more advanced stage than if it’s only in your breasts.

Is chemo necessary for HER2-negative?

Many women with hormone-positive, HER2-negative, lymph node-negative early-stage breast cancer who have intermediate risk of cancer recurrence do not need chemotherapy. The exception is that some women who are younger than 50 may benefit when chemotherapy is added to hormone therapy.

Is it better to have a mastectomy rather than a lumpectomy?

Lumpectomy and mastectomy procedures are both effective treatments for breast cancer. Research shows there is no difference in survival rate from either procedure, though lumpectomy has a slightly higher risk of recurrent cancer.

Is it good to have HER2-negative?

In normal cells, HER2 helps control cell growth. Cancer cells that are HER2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface.

How long is chemo for HER2-positive?

Neoadjuvant therapy is typically administered for between 12 and 20 weeks, depending on the chosen regimen, and followed by surgery. When given as adjuvant chemotherapy following surgery, trastuzumab is given concurrently with chemotherapy, then continued for a total duration of 12 months.

What is the survival rate of HER2-positive?

The survival rate at four years among women with HR+/HER2− is estimated to be 92.5%, followed by HR+/HER2+ at 90.3%, HR−/HER2+ at 82.7%, and HR−/HER2− at 77.0% [1]. The HER2 (human epidermal growth factor receptor 2) oncogene is positive in about 20% of primary invasive breast cancers [2].

What triggers HER2-positive?

The exact cause of HER2-positive breast cancer is unknown, but it is believed environment, lifestyle, and genetics may be factors. Risk factors for developing breast cancer in general include: Being a woman. Inherited genes, including BRCA1 and BRCA2 and others.

Does HER2+ Always Come Back?

HER2-positive breast cancer is more aggressive and more likely to recur, or return, than HER2-negative breast cancer. Recurrence can happen anytime, but it usually takes place within 5 years of treatment. The good news is that recurrence is less likely now than ever before.

How do you stop HER2 recurrence?

Vaccine Derived from HER2 Protein May Help Prevent Breast Cancer Recurrence. A new breast cancer vaccine that is derived from the HER2 protein may help prevent recurrence in patients with HER2-positive disease and appears safe.

Is HER2 curable 2021?

With recent advances in medicine, it is considered that HER2-positive breast cancer is curable. Targeted therapy is used to cure HER2-positive breast cancer. However, surgery, radiation therapy, chemotherapy and hormonal therapy may also be combined with targeted therapy depending on cancer aggressiveness.