Is ER positive breast cancer curable? ER-positive breast cancer has a high chance of being successfully treated, especially when it’s discovered early. A diagnosis at a later stage will have a less positive outlook, but being diagnosed at a later stage is less common. There are still many treatment options for late stage cancer.

What is considered ER positive breast cancer? Guidelines for the use of chemotherapy and endocrine therapy recently recommended that estrogen receptor (ER) status be considered positive if ≥1% of tumor cells demonstrate positive nuclear staining by immunohistochemistry. In clinical practice, a range of thresholds are used; a common one is 10% positivity.

Is it better to have ER positive or negative breast cancer? The survival rate for breast cancers are excellent if the cancer is detected early, and in general HR positive cancers grow slower and have a better prognosis. Overall, breast cancers that are both HR positive and HER2 negative have the best outcomes.

What are ER PR and HER2? ER = estrogen receptor, Her2 = human epidermal growth factor receptor 2, PR = progesterone receptor.

Is ER positive breast cancer curable? – Additional Questions

Is ER PR positive a good thing?

Hormone Receptor-Positive Breast Cancer

If your breast cancer has a significant number of receptors for either estrogen or progesterone, it’s considered hormone-receptor positive. Tumors that are ER/PR-positive are much more likely to respond to hormone therapy than tumors that are ER/PR-negative.

Is it good to be ER-positive?

In general, ER-positive, HER2-negative breast cancers that are low grade, strongly ER and progesterone receptor (PR) positive, with low measures of proliferation have a good prognosis with endocrine treatment alone.

What does HER2 positive mean?

HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2). This protein promotes the growth of cancer cells. In about 1 of every 5 breast cancers, the cancer cells have extra copies of the gene that makes the HER2 protein.

What is ER and PR and HER2-negative?

Triple-negative breast cancer (TNBC) is a term that has historically been applied to cancers that lack expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). TNBC tends to behave more aggressively than other types of breast cancer.

What does ER positive and PR positive mean?

If breast cancer cells have estrogen receptors, the cancer is called ER-positive breast cancer. If breast cancer cells have progesterone receptors, the cancer is called PR-positive breast cancer. If the cells do not have either of these 2 receptors, the cancer is called ER/PR-negative.

What are ER and PR receptors?

Estrogen receptor/progesterone receptor (ER/PR) tests are used to help guide breast cancer treatment. Receptors are proteins that attach to certain substances. ER/PR tests look for receptors that attach to the hormones estrogen and progesterone in a sample of breast cancer tissue.

Can you be ER positive and PR negative?

PR is an estrogen-regulated gene; ER-positive (ER+) tumors are usually also PR positive (PR+), whereas ER-negative (ER-) tumors are usually PR negative (PR-). Therefore, single HR+ (i.e., ER+/PR- or ER-/PR+) tumors represent a minority of breast cancers.

What does it mean if the lab tests say the tumor is ER and PR negative and HER2-negative?

If your tumor, or tissue sample, does not show hormone receptors, you are ER-negative, PR-negative, or negative for both. In that case, hormone therapy will most likely not be helpful to you. IHC results for HER2 are reported as 0, 1+, 2+, or 3+. A score of 0, 1+, means the tumor is HER2-negative.

How is ER and PR test done?

ER/PR testing is done using a sample of tissue taken during a biopsy. This same tissue sample is also used to diagnose cancer. The results of an ER/PR test help doctors plan treatment and understand how likely the cancer is to grow or spread.

Is HER2-negative good?

In normal cells, HER2 helps control cell growth. Cancer cells that are HER2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface.

How much does letrozole reduce risk of recurrence?

There was also a statistically significant 26% reduction in breast cancer–free interval events (3% absolute improvement) and a statistically significant 29% reduction in distant recurrences (1.8% absolute improvement) with letrozole, Dr. Mamounas reported at the 2019 San Antonio Breast Cancer Symposium.

What does it mean to be positive for an estrogen receptor?

Listen to pronunciation. (ES-truh-jin reh-SEP-ter PAH-zih-tiv) Describes cells that have a protein that binds to the hormone estrogen. Cancer cells that are estrogen receptor positive may need estrogen to grow.

What cancers are ER positive?

Hormone status of breast cancers includes: Estrogen receptor (ER) positive. The cells of this type of breast cancer have receptors that allow them to use the hormone estrogen to grow. Treatment with anti-estrogen hormone (endocrine) therapy can block the growth of the cancer cells.

Is it better to be HER2 positive or triple negative?

Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. These cancers tend to grow and spread faster than breast cancers that are HER2-negative, but are much more likely to respond to treatment with drugs that target the HER2 protein.

What cancers are caused by hormones?

People who use estrogen hormone therapy for menopause symptoms may be more prone to estrogen-dependent cancers.

Estrogen-dependent cancers include:

  • Breast cancer.
  • Ovarian cancer.
  • Uterine cancer.

Does estrogen cause hair loss?

When the levels of estrogen and progesterone drop, hair grows more slowly and becomes much thinner. A decrease in these hormones also triggers an increase in the production of androgens, or a group of male hormones. Androgens shrink hair follicles, resulting in hair loss on the head.

What cancers cause Hotflashes?

Among cancer survivors, hot flashes and sweating are common, especially in women, according to the National Cancer Institute .

Cancer Research UK note that excessive sweating can be an early sign of:

  • a carcinoid tumor.
  • an adrenal tumors.
  • Hodgkin lymphoma.
  • Non-Hodgkin lymphoma.
  • leukemia.
  • mesothelioma.
  • bone cancer.
  • liver cancer.