Is ILC breast cancer aggressive? But ILC tumors can often spread aggressively. People diagnosed with ILC are on average 3 years older at diagnosis compared with those with IDC. ILC is also most often diagnosed at a more advanced stage.

Is ILC worse than IDC? In the subgroup analysis stratified by negative hormone receptor and positive lymph node status, we found that the prognosis of ILC was significantly worse compared to IDC.

What is the best treatment for ILC? Treatment. Treatment of ILC will depend on the characteristics of the tumor present, including the type, size and spread of the tumor. Treatment will generally involve surgery to remove the abnormal cells as well as additional treatment such as radiation therapy or chemotherapy.

What causes ILC breast cancer? It’s not clear what causes invasive lobular carcinoma. Doctors know that invasive lobular carcinoma begins when cells in one or more milk-producing glands of the breast develop mutations in their DNA. The mutations lead to the inability to control cell growth, which results in the cells dividing and growing rapidly.

Is ILC breast cancer aggressive? – Additional Questions

How long can you live with invasive lobular carcinoma?

The five-year survival rate for invasive lobular carcinoma is high compared to other types of cancer — nearly 100% when treated early. If the cancer has spread to nearby tissues, the five-year survival rate is about 93%. If it has metastasized to other areas of your body, the five-year survival rate is 22%.

Does lobular breast cancer run in families?

Along with environment and lifestyle, a woman’s genetic background contributes to her risk of having breast cancer. Her risk of developing breast cancer increases if she has a family history of the disease.

How common is lobular breast cancer?

Lobular breast cancer (also called invasive lobular carcinoma) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. It is the second most common type of breast cancer, accounting for about 10% to 15% of all invasive breast cancers.

Does lobular breast cancer always recur?

Most studies report local recurrence after relatively short follow-up periods, which is usually 5 years. However there is some evidence to suggest that local recurrence may occur late in the course of follow-up.

Is lobular breast cancer fast growing?

Invasive lobular carcinoma is known for being a slow growing tumor, usually grade I or II. Slow growing, grade I tumors don’t usually respond well to chemotherapy, so hormonal therapy is key for this type of cancer.

Is lobular cancer worse than ductal?

Invasive Lobular Breast Cancer May Have Worse Prognosis than Ductal Cancer.

Where does lobular breast cancer spread first?

The cancer can be any size and may or may not have spread to nearby lymph nodes. It has spread to distant organs or to lymph nodes far from the breast. The most common sites of spread are the bone, liver, brain or lung.

Is lobular breast cancer caused by alcohol?

Drinking alcohol increased the risk of lobular, but not ductal, hormone-receptor-positive invasive breast cancer. The risk of lobular hormone-receptor-positive invasive breast cancer was 63% greater in women who drank any amount of alcohol compared to women who never drank.

Why are lobular cancers sneaky?

Instead of clustering together, lobular cells spread out single file like tree branches or spider webs or mesh, which explains why surgeons and oncologists often refer to it as “sneaky” or “insidious.” Because the cells don’t stick together well, there’s often no lump, making it harder for women to find during self-

Does ILC respond to chemo?

However, the overall consensus is that ILC responds poorly to chemotherapy with lower OS rates following NAC than observed in IDC (3, 65).

Can invasive lobular carcinoma come back?

Lobular breast cancer can recur and metastasize many years after diagnosis and treatment, so it is important to be aware of metastatic symptoms.

Is lobular carcinoma slow growing?

“Invasive lobular breast cancer is slow-growing compared to other breast cancers,” she says, “but because it is difficult to detect on a mammogram, these tumors can be large by the time they are diagnosed.”

Is lobular carcinoma hereditary?

Hereditary lobular breast cancer is a rare inherited cancer predisposition associated with pathogenic CDH1 (gene) germline mutations, and without apparent correlation with the hereditary diffuse gastric cancer syndrome.

Does lobular carcinoma metastasis?

Conclusion: Although lobular carcinoma metastasized to common metastatic sites of infiltrating ductal carcinoma, lobular carcinoma frequently metastasized to unusual sites, including the gastrointestinal tract, peritoneum, and adnexa.

Where does invasive lobular carcinoma metastasize to?

Invasive lobular carcinoma (ILC) has a greater tendency to metastasize to the peritoneum, retroperitoneum, and gastrointestinal (GI) tract as compared to invasive carcinoma of no special type (NST).

Is invasive lobular carcinoma painful?

Symptoms of Invasive Lobular Carcinoma

An area of swelling or fullness. A change to the texture of skin on your breast or nipple, like dimples or an irritated, red, or scaly area. A nipple that turns inward. Pain in your breast or nipple.

What does invasive lobular carcinoma look like on ultrasound?

The most common ultrasound manifestation of ILC is an irregular or angular mass with hypoechoic and heterogeneous internal echoes, ill-defined or speculated margins, and posterior acoustic shadowing, findings that are seen in 54%–61% of cases.