Is Luminal B breast cancer curable? Moreover, the two ER + breast cancer subtypes, luminal A and luminal B, are linked with a good prognosis and excellent long-term survival (approximately 80%–85% 5-year survival), whereas the ER negative subtypes (HER2 + and basal-like) are challenging to manage and are linked with poor prognosis (approximately 50%–60%
Is Luminal B breast cancer aggressive? Luminal B breast cancer is defined by aggressive clinical behavior and has a prognosis similar to that of non-luminal cancers (including the HER2−enriched and base-like subtypes) .
Why is it called luminal breast cancer? The tumors in the ER-positive group were characterized by the relatively high expression of many genes expressed by breast luminal cells (ER-responsive genes, luminal cytokeratins and other luminal associated markers), so they were termed the luminal group.
What is the deadliest form of breast cancer? Triple-negative breast cancer (TNBC) is considered an aggressive cancer because it grows quickly, is more likely to have spread at the time it’s found, and is more likely to come back after treatment than other types of breast cancer.